منابع مشابه
Altered factor VII activity in hemophilia.
Factor VII levels have been studied in hemophilia A and B plasmas and normal controls in a controlled, prospective study. Three assay methods were used: a standard clotting assay (FVIIc-A); a modified clotting assay (FVIIc-B) (Seligsohn et al, Blood 52:978-988, 1978); and a coupled amidolytic assay. By the FVIIc-B assay, the hemophilic plasmas were significantly lower than in the normal group (...
متن کاملUsing Factor VII in Hemophilia Gene Therapy
Human blood at physiological conditions is kept as fluid through precise system called homeostasis, if damage to the vessel, causing the system will be restored by vessel wall. Cases no regulation or homeostasis disorders, thrombosis (intravascular coagulation) or bleeding occur. In normal conditions, the secretion of vascular endothelial heparin-like and trmbomodulin molecules prevent blood co...
متن کاملThrombosis and Factor Vii Activity
The tests for the coagulation time of the blood which are in general use have contributed little to the understanding of abnormal tendencies to thrombosis, as they are extremely insensitive to all but gross changes in the coagulation mechanism. A variety of techniques have been evolved to meet this defect. One group of these methods depends on the addition of an inhibitor, e.g., heparin, to the...
متن کاملEngineered Factor VII, Factor IX, and Factor X Variants for Hemophilia Gene Therapy
The coagulation factors VII, IX, and X are all vitamin K dependent serine proteases synthesized in the liver with a high degree of similarity concerning size and structure. Factor IX is the deficient protein in hemophilia B and used in substitution therapy. The activated form of factor VII (FVIIa) is used to treat hemophilia in which the coagulant tenase complex cannot form due to inhibitory an...
متن کاملJaundice and factor VII deficiency in newborn
Resistance to thyroid hormone is an uncommon condition. We report the clinical and laboratory findings of a case with both resistance to thyroid hormone and, a reduced capacity to produce and respond to thyroid hormone. RTH is a disorder characterized by elevated circulating thyroid hormones, state of non-suppressed pituitary TSH secretion and refractoriness to hormone action in peripheral tiss...
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ژورنال
عنوان ژورنال: Blood
سال: 1985
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v65.4.845.bloodjournal654845